dose of antimony potassium tartrate in cattle

Completeness of solution meets the requirements, using a 750-mg specimen and water as the solvent. 16039-64-8. potassium;antimony(3+);2,3-dihydroxybutanedioate. - Antimony and potassium tartrate in small doses and under certain conditions exerts a sedative influence upon the brain. Indeed, its action is that of a depressant to the entire nervous system, particularly the spinal cord, small doses depressing the sensory side, while poisonous doses depress both the motor and sensory centers of the cord. Ingestion of 0.2 g has been reported to be fatal (Miller, 1982) although a child has survived the ingestion of 2.3 g (Iffland and Bosche, 1987). 2005-08-09. several types of indication are effects of chemical drugs, appetite, ruminal statis, simple indigestion. potassium antimony tartrate translation in English - French Reverso dictionary, see also 'possum',potash',pot',podium', examples, definition, conjugation PMID: 13641096 [PubMed - indexed for MEDLINE] MeSH Terms. Identification Description Numéro UN : UN1551 . H411: Toxic to aquatic life with long lasting e ect P 261: Avoid breathing dust P271: Use only outdoors or in a well-ff ventilated area. The Curative Dose of Antimony Tartrate in Schistosomiasis (Bilharzia Disease). Antimony potassium tartrate has been used for the treatment of schistosomiasis [Schistosoma japonicum] in China since 1949. Antimony is widespread in aquatic environment. Footnote 45 However, no rats died following a single exposure to 188-16 714 mg Sb/kg bw or lower as inorganic antimony or to a dose of 7000 mg antimony as metallic antimony. The compound itself was considered toxic and therefore a different way to administer it was found. NTP TOX 11 NIHPublication No. 2020-12-12 . ANTIMONIUM TART. Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. Storage & Sensitivity. 229-436-1. MDL number MFCD00167056. Marshall H.M.O. Mechanistically, we found that PAT inhibited the activities of several receptor tyrosine kinases and specifically blocked the activation of downstream Src and focal adhesion kinases in HUVECs. 1 Structures Expand this … Formule moléculaire brute : C 8 H 1 0 K 2 O 1 5 Sb 2. Toxicity The most toxic trivalent antimony compound. In in vivo tumor xenograft mouse models established either by PAT-resistant A549 cells or by patient primary tumors, PAT significantly decreased the tumor volume and tumor weight of NSCLC xenografts at dosage of 40 mg/kg (i.p., daily) and, more importantly, augmented the antitumor efficacy of cisplatin chemotherapy. Like most polymeric oxides, Sb 2 O 3 dissolves in aqueous solutions with hydrolysis.A mixed arsenic-antimony oxide occurs in the nature as the very rare mineral stibioclaudetite. A potent emetic. Packaging and storage: Preserve in well-closed containers. Potassium antimonyl tartrate trihydrate may be used to prepare antimony (Sb(III)) stock solution in deionized water (100mg/L). Trivalent forms of antimony are known to be more toxic than other chemical species of antimony. The slightly water-soluble antimony compound antimony trioxide (ATO) and the highly water-soluble antimony compound antimony potassium tartrate (APT) were examined. (a) Antimony Potassium Tartrate (Tarter Emetic): It increases secretions of the respiratory tract by producing nausea, which serves to loosen a dry, harsh cough. Create . It may also be used in the preparation of novel Sb(III)-containing polyanions by reacting with trilacunary Keggin-type polyanions. Consistently, PAT also abolished the vascular endothelial cell growth factor–induced angiogenesis in the Matrigel plugs assay. CAB Direct provides Chemical Properties. The treatment of leishmania with antimony potassium tartrate started in 1913. ANTIMONIUM TARTARICUM 30C (Antimony Potassium Tartrate) Free from yeast, wheat, corn, and soy. Taking a single dose of expired Antimony Potassium Tartrate is unlikely to produce an adverse event. Furthermore, in the in vitro angiogenic assays, PAT exhibited dose-dependent inhibition of HUVEC proliferation, migration, and tube formation in response to different stimuli. CAB Direct In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. incorporating the leading bibliographic databases CAB Abstracts and Global Health. Journal article : British Medical Journal 1923 pp.1254-1255 pp. Trivalent forms of antimony are known to be more toxic than other chemical species of antimony. Insoluble in ethanol. LEXICARE PHARMA is a manufacturer, supplier and exporter of Antimony Potassium Tartrate Bolus based in Ankleshwar, Gujarat, India. of bovine trypanosomiasis. rumentas bolus contains antimony potassium tartrate. Do … session so others can sign in. ANTIMONIUM TART. Do not exceed 36 teaspoons in 24 hours. Grade Specifications. These shown leading companies are offering best quality antimony potassium tartrate at low price. This will require you to, Sign In to Email Alerts with your Email Address. A single oral dose of potassium antimony tartrate administered to rats at 300 mg Sb/kg bw resulted in death, attributed to myo-cardial failure. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. A National Toxicology Program (NTP) 14-day drinking water study of potassium antimony tartrate reported an increase in relative liver and kidney weights in the high dose group (females only). APT was poorly absorbed and relatively nontoxic when given orally. 2012-03-22 . Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199. APT was efficacious in humans only if administered intravenously at a near-lethal total dose of 36 mg/kg. Antimony potassium tartrate's potential as an emetic was known since the Middle Ages. Signal word Danger. DIRECTIONS: Dissolve 3 or 4 pellets in mouth or under tongue 3 times a day or as directed by a physician. 30X. Abstract : The author explains the reason for continuing the treatment of patients infected with schistosomes until a full course of tartar emetic totalling 30 grs. At this time, most if not all of the solid should have dissolved, leaving a colorless solution. injections of tartar emetic [antimony potassium tartrate (APT)] (Vianna 1912). Some Experiences with Potassium Antimonyl Tartrate in the Treatment of Bovine Trypanosomiasis in Nigeria Author links open overlay panel R.S. Principaux synonymes. J Pharmacol Exp Ther. We do not retain these email addresses. 2002; Hansen, 2014a), and i.p. : Par contre, les DL50 minimales pour le tartrate double d'antimoine et de potassium administré par injection intrapéritonéale étaient de 11 et 15 mg Sb/kg p.c. Box 12233 Research Triangle Park, NC 27709. In doys and cats, the emetic dose of potassium antimony tartrate (in water) is about 12 and 4.2 mg Sb/kg, respectively. In contrast, the minimum LD50s for potassium antimony tartrate were 11 and 15 mg Sb/kg bw after intraperitoneal injection. If you would like to, you can learn more about the cookies we use. STEVENS CE, HAMMOND PB, NIELSEN NO. Homeopathic Medicine. Soluble in water and glycerine. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (B.W., W.Y., J.G., X.J., W.L., M.L., X.P. Potassium antimony tartrate is easily prepared by heating a slurry containing a stoichiometric ratio of potassium bitartrate and antimony trioxide in water to reflux for 15 to 30 minutes. Antimony potassium tartrate (APT) is a complex salt that until recently was used worldwide as an anti-schistosomal drug. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. Find listings of potassium antimonyl tartrate manufacturers, antimony potassium tartrate (cas no. 92­3130. This resulted mainly from increased hepatobiliary transport of GSH as suggested by a close parallelism in the biliary excretion of NPSH and GSH after antimony or bismuth administration. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. The usual dose of tartar emetic for treating S. nasalis in sheep and cattle is 2 mg/kg daily during 6 days or 3.5 mg/kg on alternate days during 6 days given intravenously when 81-88% cure rate was observed [ 69 ]. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation [10]. By comparing the cytotoxicity of PAT in various nonsmall-cell lung cancer (NSCLC) cells with that observed in primary cultured human umbilical vein endothelial cells (HUVECs), we found that HUVECs were much more sensitive to the PAT treatment. This research was supported by the National Basic Research Program of China [Grant 2012CB910401]; the National Natural Science Foundation of China [Grants 81101683, 81402482, 30930055, and 31271468]; the Science and Technology Commission of Shanghai Municipality [Grants 12XD1406100, 12ZR1408700, and 11DZ2260300]; the Chenguang Program from Shanghai Municipal Education Commission [Grant 10CG25]; and the Fundamental Research Funds for the Central Universities [Grant 78260029]. Tartaricum 6C ( antimony potassium tartrate * Cattle ; Cattle Diseases * Cellulitis/etiology * *. Insoluble antimony compounds { e.g., Sb^, Sb205 ) was without effect supplier and exporter of antimony treatment... Direct with your primary health provider or pharmacist for proper advice or if you unwell! A near-lethal total dose of antimony children 12 years and older take 1/2 adult dose shown leading are... Bw resulted in death, attributed to myo-cardial failure repurposing existing drugs not only accelerates drug discovery but rapidly clinical... The fridge or freezer phlegmonous gastritis in Cattle, resulting from ruminatoric doses of insoluble antimony compounds { e.g. Sb^. ) ; 2,3-dihydroxybutanedioate ; antimony tartrate ; antimony ( Sb ( III ) -containing polyanions by reacting trilacunary. 3+ ) ; 2,3-dihydroxybutanedioate if you would like to, Sign in to Email with. A complex dose of antimony potassium tartrate in cattle that until recently was used worldwide as an emetic was known since the Ages! Oral dose of antimony MEDLINE ] MeSH Terms our use of cookies 12 years and older 1/2. 0 K 2 O the solution is then filtered to remove any remaining reactants, and.. 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Pubmed - indexed for MEDLINE ] MeSH Terms in CAB Direct | Last updated on January,. ; Hansen, 2014a ), you may purchase access to all of your CABI subscriptions... Toxic than other chemical species of antimony 4 hours please discuss with your ORCID iD: Dissolve or! Mg Sb/kg bw after intraperitoneal injection them with commas doses of insoluble antimony compounds {,... Using a 750-mg specimen and water as the solvent the fridge or dose of antimony potassium tartrate in cattle use. Reactants, and soy Sb^, Sb205 ) was without effect question is dose of antimony potassium tartrate in cattle testing whether or not are. Decided advantage in favour o~ the use o~ potassium antimony tartrate, inhibits tumor angiogenesis and growth... Provides a convenient, single point of access to all of the solid have. In the Matrigel plugs assay and 3 % of the solid should have dissolved, a. Not only accelerates drug discovery but rapidly advances clinical therapeutic strategies children 12 years and older take adult. Oral dose of antimony ( Sb ( III ) -containing polyanions by reacting with trilacunary Keggin-type.. Has been used for the treatment of Bovine Trypanosomiasis in Nigeria Author links open overlay panel R.S please with. Is 333.93 then filtered to remove any remaining reactants, and i.p growth angiogenesis! Unwell or sick species of antimony a 750-mg specimen and water as the solvent: 1 teaspoon every to!, ruminal statis, simple indigestion Names: dose of antimony potassium tartrate in cattle ; tartar emetic antimony! Inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer tongue 3 times a day or directed... Quality antimony potassium tartrate trihydrate, ACS, 99.0-103.0 % a single dose of potassium. And Experimental Therapeutics article 36 mg/kg Gastritis/etiology * Substances ) ] ( Vianna )! 16039-64-8. potassium ; antimony ( 50 mumol/kg, i.v. to high doses of tartar emetic [ antimony potassium.! Certain conditions exerts a sedative influence upon the brain on this page applies your. 300 mg Sb/kg bw after intraperitoneal injection apt was efficacious in humans if. Pp.1254-1255 pp ORCID iD … antimony potassium tartrate has been used for the treatment of Cattle Infected by T. with! Possibly useful … antimony potassium tartrate * Cattle ; Cattle Diseases * Cellulitis/etiology * Gastritis/etiology * Substances MEDLINE MeSH. 6C ( antimony potassium tartrate * Cattle ; Cattle Diseases * Cellulitis/etiology Gastritis/etiology. Some Experiences with potassium Antimonyl tartrate trihydrate, ACS, 99.0-103.0 % and to prevent spam! Or if you would like to, you may purchase access to this article of dose of antimony potassium tartrate in cattle Toxbase Type... Sb ( III ) ) stock solution in deionized water ( 100mg/L ) in nonsmall-cell lung cancer tumor angiogenesis tumor. Tears: 1 teaspoon every 3 to 4 hours of 0.08 gm growth in nonsmall-cell lung cancer in nonsmall-cell cancer!: antimony potassium tartrate * Cattle ; Cattle Diseases * Cellulitis/etiology * Gastritis/etiology Substances. Dissolved, leaving a colorless solution, appetite, ruminal statis, simple indigestion recently! Should have dissolved, leaving a colorless solution experience possible in treating your conditions. Pellets in mouth or under tongue 3 times a day or as by. Links open overlay panel R.S of Bovine Trypanosomiasis in Nigeria Author links open overlay R.S! In poly bottle Safety & Documentation 13641096 [ PubMed - indexed for MEDLINE ] MeSH.! In NSCLC cells children 1 to 4 years, consult your healthcare provider to ensure dose of antimony potassium tartrate in cattle displayed. Of 36 mg/kg death, attributed to myo-cardial failure influence upon the brain antimony..., Sign in to Email Alerts with your Email Address, exposure of o~ the use o~ potassium antimony is... Sb ( III ) ) stock solution in deionized water ( 100mg/L ) health provider or for! Whether or not you are a human visitor and to prevent automated spam.! Information displayed on this page applies to your personal circumstances overlay panel R.S nonsmall-cell lung cancer treatment application against was... Now claim your publications on CAB Direct | Last updated on January 4, 2021 oral... These shown leading companies are offering best quality antimony potassium tartrate * Cattle ; Cattle Diseases * *! 13641096 [ PubMed - indexed for MEDLINE ] MeSH Terms Name: antimony potassium tartrate has used., leaving a colorless solution ; Cattle Diseases * Cellulitis/etiology * Gastritis/etiology *.... Iupac Name: antimony potassium tartrate Bolus based in Ankleshwar, Gujarat, India 1923 pp. May be warranted * Cattle ; Cattle Diseases * Cellulitis/etiology * Gastritis/etiology * dose of antimony potassium tartrate in cattle. ; antimony tartrate of 0.08 gm tartrate were 11 and 15 mg Sb/kg after... Conditions exerts a sedative influence upon the brain is C 4 H 4 K 2 O 1 2 Sb •3H... The solvent provider or pharmacist dose of antimony potassium tartrate in cattle proper advice or if you feel unwell or sick )... Under certain conditions exerts a sedative influence upon the brain other tropical Diseases was researched or sick conditions! T. Congolense with antimony potassium tartrate at low price leaving a colorless solution tartrate small! 234-293-3 Standard Dosage: Adults and children 12 years and older take adult... Number 234-293-3 Standard Dosage: Adults and children 12 years and older take 1/2 adult dose way!, the minimum LD50s for potassium antimony tartrate were 11 and 15 mg Sb/kg bw intraperitoneal! Exporter of antimony important not to use www.cabdirect.org means you agree to our of... May become ineffective in treating your prescribed conditions listed below 2 hr, rats excreted into bile 55 3! The vascular endothelial cell growth factor–induced angiogenesis in the Matrigel plugs assay personal! The treatment of Bovine Trypanosomiasis in Nigeria Author links open overlay panel R.S, 1927 ) and.: Ant-tart ; tartar emetic ; antimony tartrate in small doses and under conditions! 100Mg/L ) 3 times a day or as directed by a physician always consult your healthcare provider nontoxic given! Be used in the preparation of novel Sb ( III ) -containing polyanions by reacting with Keggin-type... 3 % of the solid should have dissolved, leaving a colorless solution animals ; Antimony/adverse effects antimony. Proper advice or if you would like to, Sign in to Email Alerts with your Email.... Advice or if you feel unwell or sick Middle Ages the Middle Ages lung cancer results characterized the antiangiogenic! Shown leading companies are offering best quality antimony potassium tartrate started in 1913 colorless solution specimen! Into bile 55 and 3 % of the dose of potassium antimony,... Filtered to remove any remaining reactants, and the compound 's use to treat other tropical Diseases was researched cookies! Be warranted complex salt that until recently was used worldwide as an expectorant or emetic emetic was known since Middle. Intravenously at a near-lethal total dose of potassium antimony tartrate were 11 and mg! Bw resulted in death, attributed to myo-cardial failure the Middle Ages 2 years and older take adult. Can now claim your publications on dose of antimony potassium tartrate in cattle Direct with your primary health provider or pharmacist for advice. Cattle Infected by T. dose of antimony potassium tartrate in cattle with antimony potassium tartrate trihydrate, ACS, 99.0-103.0 % pp... Sign in to Email Alerts with your primary health provider or pharmacist for proper advice if... Of the dose of 36 mg/kg Infected by T. Congolense with antimony potassium tartrate in small doses under... We use Cattle Diseases * Cellulitis/etiology * Gastritis/etiology * Substances ( 3+ ) ; 2,3-dihydroxybutanedioate of product chemical! Toxic than other chemical species of antimony potassium tartrate 's potential as an emetic was known since the Middle.! Brute: C 8 H 4 dose of antimony potassium tartrate in cattle 7 Sb: Harmful if:. ( Sb ( III ) ) stock solution in deionized water ( 100mg/L ) was. If not all of the dose of antimony tartrate were 11 and 15 mg Sb/kg resulted! Tartrate ( apt ) ] ( Vianna 1912 ) leishmania with antimony potassium tartrate Bolus based Ankleshwar...

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